Lirio, founded in 2017 and based in Knoxville, Tennessee, provides a personalization engine for digital health that combines behavioral science with artificial intelligence. The platform orchestrates hyper-personalized healthcare communications and interventions by integrating with existing technology stacks used by health systems, life sciences organizations, and payers.
The company's approach rests on what it describes as the world's first Large Behavior Model for healthcare, a proprietary foundation model that enables real-time, individualized behavior-change interventions. Rather than relying on demographic segmentation, the platform adapts in real time based on clinical history, social context, and behavioral factors. This is powered by Lirio's Precision Nudging™ technology, designed to deliver one-to-one personalization at scale across the care continuum.
Lirio addresses challenges spanning patient acquisition, preventive care, chronic disease management, and care transitions. The company claims its platform helps close care gaps, improve population health outcomes, and reduce total cost of care by delivering scalable, AI-driven engagement tailored to each patient's unique healthcare journey.






